Factors affecting outflow facility calculations
نویسندگان
چکیده
منابع مشابه
Physical Factors Affecting Outflow Facility Measurements in Mice.
PURPOSE Mice are commonly used to study conventional outflow physiology. This study examined how physical factors (hydration, temperature, and anterior chamber [AC] deepening) influence ocular perfusion measurements in mice. METHODS Outflow facility (C) and pressure-independent outflow (Fu) were assessed by multilevel constant pressure perfusion of enucleated eyes from C57BL/6 mice. To examin...
متن کاملExcimer laser effects on outflow facility and outflow pathway morphology.
PURPOSE To determine the relative contributions to aqueous outflow resistance of the tissues distal to the inner wall of Schlemm's canal. METHODS While performing constant pressure perfusion at 10 mm Hg, a 193-nm excimer laser (Questek) was used to precisely remove portions of sclera, unroofing Schlemm's canal while leaving the inner wall intact. The laser beam was masked to produce a beam 2 ...
متن کاملEffect of Tonography on Facility of Outflow.
In enucleated stored eyes facility of outflow is diminished by large corneal distortions. The radius of distortion at which decrease in facility is noted is related to the shape of the distortion. Of the three distorting devices tested, a plane surface decreased the facility at the smallest radius of distortion, a convex surface was intermediate in effect, while the Schiotz tonometer allowed th...
متن کاملChoroid tension and facility of aqueous outflow.
Tension of the choroid of enucleated eyes was adjusted by incising the sclera and lengthening the eye. The facility of outflow increased in direct proportion to choroid stretch. The present results are compared with reported results of anterior chamber deepening and lens depression in vitro and with accommodation and goniospasis in vivo. Choroid stretch in the enucleated eye is less efficient i...
متن کاملPigment epithelium-derived factor decreases outflow facility.
PURPOSE Pigment epithelium-derived factor (PEDF) regulates blood-retinal barrier function. As a constituent of aqueous humor, the role of PEDF in conventional outflow function is unknown. The goals of the study were to examine the effects of PEDF on barrier function of cultured Schlemm's canal (SC) endothelia and outflow facility in mouse eyes in situ. METHODS To model the inner wall of SC, t...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2006
ISSN: 0014-4835
DOI: 10.1016/j.exer.2006.08.008